\documentclass[10pt, a5paper]{article} \usepackage[utf8]{inputenc} \usepackage[T1]{fontenc} %\usepackage[english, ngerman]{babel} \usepackage{csquotes} \usepackage[english]{babel} \usepackage{graphicx} \usepackage{parskip} \usepackage{caption} \usepackage{subcaption} \usepackage{adjustbox} \usepackage{nicematrix} \usepackage{fancyhdr} \usepackage{blindtext} \usepackage[left=1cm, right=1cm, top=1.5cm, bottom=1.5cm]{geometry} %\usepackage[table]{xcolor} \usepackage{color} \usepackage[colorlinks]{hyperref} \usepackage{tcolorbox} \tcbuselibrary{most} \pagestyle{plain} % Code listing \usepackage{listings} \definecolor{bgtinted}{HTML}{efefef} \definecolor{codegray}{HTML}{111111} \definecolor{codeorange}{HTML}{91632C} \definecolor{codegreen}{HTML}{3D5232} \definecolor{codepurple}{HTML}{4E3A52} \lstdefinestyle{mystyle}{ backgroundcolor=\color{black!5!white}, commentstyle=\color{codepurple}, keywordstyle=\color{codegray}, stringstyle=\color{codegreen}, basicstyle=\ttfamily\scriptsize\color{codegray}, breakatwhitespace=true, breaklines=true, captionpos=b, keepspaces=true, showspaces=false, showstringspaces=false, showtabs=false, tabsize=2 } \lstset{style=mystyle} % Citations %\usepackage{cite} \usepackage[backend=biber, style=vancouver]{biblatex} \addbibresource{../bibliography/bibliography.bib} % Colors \definecolor{PLRI_Rot}{RGB}{190,30,60} \definecolor{grau}{RGB}{120,110,100} \begin{document} {\fontfamily{phv}\selectfont} \input{cover.tex} \section{Background} Clinical deterioration is a critical concern in healthcare, particularly for vulnerable populations such as the elderly and chronically ill patients. It refers to a decline in a patient's health status and may lead to adverse outcomes, including hospitalization, longer stays in intensive care units, and increased healthcare costs. Early warning scores (EWS) have been widely adopted internationally for preemptive detection of deteriorating patients\cite{downey_strengths_2017}. A large body of scientific evidence validates the effectiveness of EWS in assessing severity of illness, and in predicting adverse clinical events, such as severe deterioration, likelihood of intensive care unit (ICU) admission, and mortality, both in hospital wards\cite{subbe_validation_2001, buist_association_2004, paterson_prediction_2006, alam_exploring_2015, bilben_national_2016, brekke_value_2019} and in ambulatory care \cite{ehara_effectiveness_2019, burgos-esteban_effectiveness_2022, paganelli_conceptual_2022}. Two commonly used clinical scores are the \textit{National Early Warning Score 2} (NEWS2) and the \textit{Modified Early Warning Score} (MEWS)\cite{burgos-esteban_effectiveness_2022}. Both are calculated by capturing various vital parameters from the patient at a specific point in time, followed by numerical aggregation of the captured data according to the score being used\cite{subbe_validation_2001, noauthor_national_2017}. For MEWS, each measured physiological parameter is assigned an individual score based on which range it is in. The ranges for scoring each parameter are shown in Table \ref{mews-table}. The individual scores are then added together to produce the final MEWS. \begin{table}[!h] \noindent\adjustbox{max width=\textwidth}{ \begin{NiceTabular}{l>{\columncolor{red!15}}c>{\columncolor{orange!15}}c>{\columncolor{yellow!15}}c>{\columncolor{green!15}}c>{\columncolor{yellow!15}}c>{\columncolor{orange!15}}c>{\columncolor{red!15}}c}[hvlines,colortbl-like] \hline Individual Score & $\mathbf{+3}$ & $\mathbf{+2}$ & $\mathbf{+1}$ & $\mathbf{+0}$ & $\mathbf{+1}$ & $\mathbf{+2}$ & $\mathbf{+3}$ \\ \hline \textbf{Systolic Blood Pressure} [mmHg] & $<70$ & $71-80$ & $81-100$ & $101-199$ & & $\geq 200$ & \\ \hline \textbf{Heart Rate} [bpm] & & $<40$ & $41-50$ & $51-100$ & $101-110$ & $111-129$ & $\geq 130$ \\ \hline \textbf{Respiratory Rate} [bpm] & & $<9$ & & $9-14$ & $15-20$ & $21-29$ & $\geq 30$ \\ \hline \textbf{Temperature} [°C] & & $<35$ & & $35-38.4$ & & $\geq 38.5$ & \\ \hline \textbf{AVPU} & & & & alert & reacting to voice & reacting to pain & unresponsive \\ \hline \end{NiceTabular} } \caption{\label{mews-table}MEWS calculation ranges} \end{table} Traditionally, doctors and nursing staff perform collection and evaluation of the data manually, often inputting data into an EWS-calculator by hand. However, as Eisenkraft et al. mentioned in 2023, ``some known setbacks of the NEWS and other scales are the frequency of scoring and response, integration into practice, and miscalculation by healthcare providers [...]''\cite{eisenkraft_developing_2023}{(p.2)}. Remote patient monitoring (RPM) can improve deterioration detection\cite{shaik_remote_2023} by greatly reducing the amount of human interaction required to take measurements and perform EWS calculations. A number of studies have explored RPM combined with automated EWS calculation in hospitals\cite{eisenkraft_developing_2023, filho_iot-based_2021, un_observational_2021, karvounis_hospital_2021}. With hospitals facing overwhelming patient load during the SARS-CoV-2 pandemic, interest in exploring remote patient monitoring options surged, and NEWS2 emerged as an effective tool for predicting severe infection outcomes\cite{filho_iot-based_2021, gidari_predictive_2020, otoom_iot-based_2020, carr_evaluation_2021} while reducing person-to-person contact during patient monitoring. Since then, a variety of wearable medical sensors capable of continuously recording vital parameters have been developed and are commercially available\cite{noauthor_visi_nodate, noauthor_equivital_nodate, noauthor_vitls_nodate, noauthor_caretaker_nodate, noauthor_medtronic_nodate}. %Javanbakht et al. found that continuous vitals monitoring is more cost-effective than intermittent monitoring\cite{javanbakht_cost_2020}, however the findings of this study should be taken lightly due to potential bias reporting. \section{Review of existing literature} In order to examine the current state of scientific knowledge about the use of wearable devices for automated EWS monitoring of patients at home, a comprehensive review of the existing literature was conducted. By systematically examining and synthesizing the current body of knowledge, this review identified a variety of approaches for utilizing smart medical devices in post-discharge patient care, as well as existing limitations and challenges in future research in this rapidly evolving field. \subsection{Search strategy} A systematic search strategy was implemented on the Scopus database, aimed to encompass a broad spectrum of literature relevant to the use of smart medical devices for automated early warning score monitoring of patients dismissed from ambulant or hospital care. The search focused on topics related to the research area, encompassing the examination of EWS, hospital admission, care escalation, and medical emergencies in combination with IT automation, medical wearables and Internet of Things (IoT). The Scopus database was chosen for its extensive coverage of scholarly literature across multiple disciplines. For the search strategy, the following inclusion and exclusion criteria were employed to select relevant articles: Inclusion criteria: \begin{itemize} \item Articles focusing on the utilization of medical wearable devices for remote patient monitoring \item Articles addressing the automated calculation of early warning scores \item Articles discussing the application of early warning scores outside of medical care facilities \end{itemize} Exclusion criteria: \begin{itemize} \item Non-English language articles \item Publications for which full-text access was not available \item Duplicate articles \item Articles outside of the \enquote{Computer Science} subject area \end{itemize} The following Scopus query was used to identify relevant literature: \begin{tcolorbox}[enhanced, center, width=0.95\linewidth, rounded corners=all, colframe=black!75!white, boxrule=0.5pt, colback=black!5!white] \begin{lstlisting}[language=SQL] TITLE-ABS-KEY(("patient" OR "clinical" OR "medical") AND ("deterioration" OR "instability" OR "decompensation" OR "admission" OR "hospitalization" OR "escalation" OR "triage" OR "emergency")) OR ("early warning" OR "early warning score" OR "warning" OR "score*" OR "EWS") AND TITLE-ABS-KEY("system" OR "automat*" OR "smart*" OR "wearable*" OR "internet of thing*" OR "iot" OR "digital" OR "sensor*" OR "signal" OR "intelligen*" OR "predict*" OR "monitor*" OR "sreen*" OR "remote" OR "it" OR "comput*" OR "mobile" OR "5G" OR "network" (("vital*" OR "bio*") AND ("marker*" OR "sign*" OR "monitor*"))) AND TITLE-ABS-KEY("home" OR "domestic" OR "community" OR "remote" OR "longterm" OR "nursing" OR "rehabilitation" OR "outof*hospital" OR "telemedicine" OR "ehealth" OR "mhealth") \end{lstlisting} \end{tcolorbox} \subsection{Results} \begin{figure}[h] \begin{center} \includegraphics[width=.5\textwidth]{./figures/prisma-flowchart.png} \caption{\label{prisma-flowchart}PRISMA flowchart showing screening and assessment of identified literature} \end{center} \end{figure} An initial query on Scopus yielded a total of $N=1997$ records. After removing duplicates, $N=952$ records were excluded, resulting in $N=1045$ unique records. Upon screening the titles and abstracts, $N=963$ records did not meet the inclusion criteria, leaving $N=82$ articles to be assessed for eligibility in full text. Finally, after a thorough evaluation, $N=45$ articles were included for the literature review, providing insight into the current state of research on the use of smart medical devices for automated early warning score monitoring in patients transitioning from ambulant or hospital care. Figure \ref{prisma-flowchart} shows the literature assessment process. The list of reviewed literature is shown in Table \ref{inclusion-table}. \begin{table}[!h] \adjustbox{max width=\textwidth}{ \begin{NiceTabular}{rll}[hvlines,colortbl-like] \hline \textbf{Number} & \textbf{Title} & \textbf{Author(s), Year} \\ \hline 1 & Internet of things enabled in-home health monitoring system using early warning score\cite{anzanpour_internet_2015} & Anzanpour 2015 \\ \hline 2 & Context-Aware Early Warning System for In-Home Healthcare Using Internet-of-Things\cite{anzanpour_context-aware_2016} & Anzanpour 2016 \\ \hline 3 & An IoT based system for remote patient monitoring\cite{archip_iot_2016} & Archip 2016 \\ \hline 4 & Wireless sensor network-based smart room system for healthcare monitoring\cite{arnil_wireless_2011} & Arnil 2011 \\ \hline 5 & Design and Development of IOT Based Multi-Parameter Patient Monitoring System\cite{athira_design_2020} & Athira 2020 \\ \hline 6 & Medical warning system based on Internet of Things using fog computing\cite{azimi_medical_2016} & Azimi 2016 \\ \hline 7 & Self-aware early warning score system for IoT-based personalized healthcare\cite{azimi_self-aware_2017} & Azimi 2017 \\ \hline 8 & Review on IoT based Healthcare systems\cite{b_v_review_2022} & Krishna 2022 \\ \hline 9 & Effectiveness of Early Warning Scores for Early Severity Assessment in Outpatient Emergency Care: A Systematic Review\cite{burgos-esteban_effectiveness_2022} & Burgos-Esteban 2022 \\ \hline 10 & A QRS Detection and R Point Recognition Method for Wearable Single-Lead ECG Devices\cite{chen_qrs_2017} & Chen 2017 \\ \hline 11 & Adopting the Internet of Things technologies in health care systems\cite{chiuchisan_adopting_2014} & Chiuchisan 2014 \\ \hline 12 & An Efficient Wireless Health Monitoring System\cite{chowdary_efficient_2018} & Chowdary 2018 \\ \hline 13 & DeepSigns: A predictive model based on Deep Learning for the early detection of patient health deterioration\cite{da_silva_deepsigns_2021} & da Silva 2021 \\ \hline 14 & Use of ultra-low cost fitness trackers as clinical monitors in low resource emergency departments\cite{dagan_use_2020} & Dagan 2020 \\ \hline 15 & A data fusion algorithm for clinically relevant anomaly detection in remote health monitoring\cite{de_mello_dantas_data_2020} & de Mello Dantas 2020 \\ \hline 16 & Patient attitudes towards remote continuous vital signs monitoring on general surgery wards: An interview study\cite{downey_strengths_2017} & Downey 2018 \\ \hline 17 & Developing a real-time detection tool and an early warning score using a continuous wearable multi-parameter monitor\cite{eisenkraft_developing_2023} & Eisenkraft 2023 \\ \hline 18 & An IoT-Based Healthcare Platform for Patients in ICU Beds During the COVID-19 Outbreak\cite{filho_iot-based_2021} & Filho 2021 \\ \hline 19 & Patient Monitoring System Based on Internet of Things\cite{gomez_patient_2016} & Gomez 2016 \\ \hline 20 & Continuous monitoring is superior to manual measurements in detecting vital sign deviations in patients with COVID-19\cite{gronbaek_continuous_2023} & Gronbaek 2023 \\ \hline 21 & Secure and lightweight privacy preserving Internet of things integration for remote patient monitoring\cite{imtyaz_ahmed_secure_2022} & Imtyaz 2022 \\ \hline 22 & Remote Continuous Health Monitoring System for Patients\cite{jagadish_remote_2018} & Jagadish 2018 \\ \hline 23 & Cost utility analysis of continuous and intermittent versus intermittent vital signs monitoring in patients admitted to surgical wards\cite{javanbakht_cost_2020} & Javanbakht 2020 \\ \hline 24 & Wearable sensors to improve detection of patient deterioration\cite{joshi_wearable_2019} & Joshi 2019 \\ \hline 25 & Intelligent Healthcare\cite{kale_intelligent_2021} & Kale 2021 \\ \hline 26 & A Hospital Healthcare Monitoring System Using Internet of Things Technologies\cite{karvounis_hospital_2021} & Karvounis 2021 \\ \hline 27 & All-day mobile healthcare monitoring system based on heterogeneous stretchable sensors for medical emergency\cite{lee_all-day_2020} & Lee 2020 \\ \hline 28 & Analysis of the early warning score to detect critical or high-risk patients in the prehospital setting\cite{martin-rodriguez_analysis_2019} & Martin-Rodriguez 2019 \\ \hline 29 & An IoT-based framework for early identification and monitoring of COVID-19 cases\cite{otoom_iot-based_2020} & Otoom 2020 \\ \hline 30 & A conceptual IoT-based early-warning architecture for remote monitoring of COVID-19 patients in wards and at home\cite{paganelli_conceptual_2022} & Paganelli 2022 \\ \hline 31 & Personalized Mobile Health for Elderly Home Care: A Systematic Review of Benefits and Challenges\cite{pahlevanynejad_personalized_2023} & Pahlevanynejad 2023 \\ \hline 32 & CuraBand: Health Monitoring and Warning System\cite{phaltankar_curaband_2021} & Phaltankar 2021 \\ \hline 33 & Internet of Things in Healthcare, A Literature Review\cite{quraishi_internet_2021} & Quraishi 2021 \\ \hline 34 & Vital Sign Monitoring System for Healthcare Through IoT Based Personal Service Application\cite{sahu_vital_2022} & Sahu 2022 \\ \hline 35 & Internet-of-Things-Enabled Early Warning Score System for Patient Monitoring\cite{sahu_internet--things-enabled_2022} & Sahu 2022 \\ \hline 36 & Cloud-Based Remote Patient Monitoring System with Abnormality Detection and Alert Notification\cite{sahu_cloud-based_2022} & Sahu 2022 \\ \hline 37 & Remote patient monitoring using artificial intelligence: Current state, applications, and challenges\cite{shaik_remote_2023} & Shaik 2023 \\ \hline 38 & Prototype development of continuous remote monitoring of ICU patients at home\cite{thippeswamy_prototype_2021} & Thippeswamy 2021 \\ \hline 39 & IoT based Smart Healthcare Monitoring Systems: A Review\cite{tiwari_iot_2021} & Tiwari 2021 \\ \hline 40 & Observational study on wearable biosensors and machine learning-based remote monitoring of COVID-19 patients\cite{un_observational_2021} & Un 2021 \\ \hline 41 & Adaptive threshold-based alarm strategies for continuous vital signs monitoring\cite{van_rossum_adaptive_2022} & van Rossum 2022 \\ \hline 42 & A retrospective comparison of the Modified Early Warning Score (MEWS) and machine learning approach\cite{wu_predicting_2021} & Wu 2021 \\ \hline 43 & IoT based Real Time Health Monitoring\cite{yeri_iot_2020} & Yeri 2020 \\ \hline 44 & Vital Signs Prediction and Early Warning Score Calculation Based on Continuous Monitoring of Hospitalised Patients Using Wearable Technology\cite{youssef_ali_amer_vital_2020} & Youssef Ali Amer 2020 \\ \hline 45 & Features of electronic Early Warning systems which impact clinical decision making\cite{zarabzadeh_features_2012} & Zarabzadeh 2012 \\ \hline \end{NiceTabular} } \caption{\label{inclusion-table}List of included articles} \end{table} % TODO for all outcomes, present and compare the findings of each study \subsection{Discussion} While the application of EWS in ambulant care facilities and hospitals has been thoroughly investigated, very little research has been done to assess their practicability for remote monitoring of at-risk patients at home. Furthermore, it was observed that previous research on the use of IoT-devices for this purpose was largely conducted in experimental settings, limiting the generalizability of the results. Some studies have examined monitoring vital signs of at-home-patients for abnormalities, however in most of them, no automated EWS calculations were made\cite{archip_iot_2016, azimi_medical_2016, chowdary_efficient_2018, yeri_iot_2020, lee_all-day_2020, athira_design_2020, phaltankar_curaband_2021, thippeswamy_prototype_2021}. In 2015, Anzanpour et al. developed a monitoring system which collects vitals data and calculates EWS, however due to limited or nonexistent availability of wireless sensors for all relevant vital signs, the work was limited to using a laboratory prototype and required manual interaction in transferring vitals data\cite{anzanpour_internet_2015}. Sahu et al. documented their development of an EWS-supported digital early warning system using the PM6750\cite{sahu_internet--things-enabled_2022}, an experimental vitals data monitoring device capable of taking continuous measurements in a laboratory setting\cite{noauthor_pm6750_nodate}. However, the methodology they used to calculate EWS in real-time with laboratory data is both inconsistent and weak. Recent studies indicate a growing trend towards investigating automated EWS calculations in real-world scenarios\cite{downey_strengths_2017, karvounis_hospital_2021, b_v_review_2022, dagan_use_2020}. Notably, the availability of comprehensive, mobile vital signs monitoring equipment has seen a significant increase, especially in the wake of the COVID-19 pandemic\cite{paganelli_conceptual_2022, filho_iot-based_2021, otoom_iot-based_2020, gronbaek_continuous_2023}. This surge in accessibility has paved the way for more extensive and continuous monitoring of patients in non-medical care settings. Moreover, there is a growing interest in incorporating machine learning algorithms to enhance the predictive capabilities of deterioration detection\cite{un_observational_2021, da_silva_deepsigns_2021, de_mello_dantas_data_2020}. This demonstrates the evolving landscape of remote patient monitoring, aiming to improve clinical outcomes and alleviate the burden on hospital wards. Despite the wealth of literature reviewed, no existing empirical studies evaluating the use of early warning scores for patients at home were identified. This highlights a crucial research gap and prompts the need for further investigation in this area, potentially warranting the development of an EWS specialized for use outside of medical care facilities. \subsection{Interpretation of Results} Based on the findings, several key implications can be drawn. Firstly, the improved availability of smart sensors and the demonstrated effectiveness of EWS in predicting deterioration in direct medical care settings warrant research into their utilization at home. By remotely monitoring patients, it may be possible to identify early signs of deterioration, enabling earlier dismissal from hospital care and thereby freeing up valuable resources. Additionally, this approach holds the potential to reduce mortality rates and minimize the frequency of adverse clinical outcomes. However, it is important to acknowledge the lack of research on the use of EWS at home, which calls for a feasibility study in this specific context. This study would need to address challenges such as the frequency of measurements required and the absence of immediate diagnosis from qualified medical staff. Overcoming these obstacles is essential to ensure the safety and efficacy of automated remote patient monitoring in home-based settings. In conclusion, the literature review highlights the increasing interest in using smart medical devices and EWS for remote patient monitoring, particularly in real-world scenarios. The absence of studies evaluating the application of EWS in patients at home underscores the need for further investigation in this area. Conducting a feasibility study to explore the practicality and challenges of implementing EWS in home-based care would contribute significantly to the existing body of knowledge and help advance the field of automated early warning score monitoring in non-medical care settings. \section{Motivation} % TODO EWS makes prediction value better than monitoring abnormalities in single vital signs Installing and operating traditional continuous monitoring systems, like the vital sign monitors used in medical facilities, demands specialized equipment and technical expertise. Furthermore, these systems are cumbersome for patients, as they involve connecting patient and sensor device with numerous electrodes and cables, restricting patient mobility to the bed area, and physically tying the monitoring equipment to a single location. Conversely, battery-powered, wireless vitals monitoring devices, such as wearable armbands or smartwatches, can combine several biometric sensors into one device, allowing for a much higher degree of patient mobility, faster deployment and better scalability\cite{un_observational_2021}. Therefore, utilizing such devices for RPM is a suitable approach. In summary, with the current availability of wearable, networked biosensors and the validated effectiveness of EWS in medical facilities, combining both aspects presents an important and interesting research opportunity which could help reduce mortality and improve clinical outcomes for patients at risk of deterioration, both in their homes and on the go. %Patients appreciate the face-to-face aspect of early warning score monitoring as it allows for reassurance, social interaction, and gives them further opportunity to ask questions about their medical care\cite{downey_patient_2018}. %Taking continuous measurements is superior to measuring intermittently\cite{gronbaek_continuous_2023, shaik_remote_2023}. \section{Objectives} The objective of this research is to explore the practical feasibility of using an existing, clinically validated EWS to remotely monitor patients who are still at risk of deterioration after having been dismissed from medical care facilities, utilizing smart medical sensor devices. Taking measurements using the devices should be as easy and unintrusive as possible for the patient, enabling them to take vital sign readings easily from the comfort of their home or while out of the house. This will be accomplished by developing and subsequently evaluating a digital system capable of capturing, processing and monitoring patient vitals data. The system will consist of a network of smart medical sensors and a centralized web application used to store and process the data. Patients and, potentially, medical staff can interact with the application to visualize and utilize captured data. In addition to monitoring individual physiological parameters for abnormalities, the application will calculate the patient's current MEWS, and send alerts when an increased risk of deterioration is detected. A visualization depicting the main flow of data in the system is shown in Figure \ref{system-components-macro}. \begin{center} \begin{figure}[h] \includegraphics[width=\textwidth]{../figures/components-macro.png} \caption{\label{system-components-macro}Data flow of the proposed early warning system} \end{figure} \end{center} The following vital signs will be captured and processed by the application: \begin{itemize} \item Heart Rate (HR) \item Blood Pressure (BP) \item Body Temperature (TEMP) \item Blood Oxygen Saturation (SPO2) \item Respiratory Rate (RR) \footnote{ Determining the respiration rate of a mobile subject accurately using currently available electronic monitoring equipment presents a major challenge. Leveraging available SPO2 readings alongside asking the subject whether they are experiencing any shortness of breath may, however, provide a suitable compromise. } \item AVPU Score \footnote{ Determining the AVPU score of a patient requires examination by qualified medical staff, but prompting the user to answer a simple question coherently to determine whether they are alert or not may be a suitable option. } \end{itemize} The devices listed in Table \ref{device-table} will be used to measure the patient's vital signs, while the web application and its alert system prompts the patient periodically to take new measurements. \begin{table}[!h] \noindent\adjustbox{max width=\textwidth}{ \begin{NiceTabular}{lll}[hvlines,colortbl-like] \hline \textbf{Device Name} & \textbf{Device Type} & \textbf{Captured Vitals Parameter} \\ \hline \href{https://www.withings.com/de/en/scanwatch}{Withings Scanwatch} & Wearable Smartwatch & HR, SPO2, RR (while asleep) \\ \hline \href{https://www.withings.com/de/en/thermo}{Withings Thermo} & Handheld Smart Thermometer & TEMP \\ \hline \href{https://www.withings.com/de/en/bpm-core}{Withings BPM Core} & Smart Blood Pressure Cuff & BP, HR \\ \hline Patient's phone & Smartphone & AVPU \\ \hline \end{NiceTabular} } \caption{\label{device-table}Smart devices used for data capture} \end{table} Following the technical implementation of the described system, its day-to-day usability and effectiveness will be evaluated in a case study. Over the course of a week, a test subject, representing a patient recently dismissed from an accident and emergency hospital department (A\&E) will be using the system both at home and while out and about. While awake, the patient will be prompted by the system via smartphone notifications to take new measurements every two hours. The captured data and resulting MEWS records will be periodically reviewed by another person representing medical staff during this time. Overall, the proposed research is aimed at answering the following scientific inquiries: \begin{enumerate} \item What are the challenges of developing and utilizing a remote patient monitoring system using smart medical sensors, given the currently available technology? \item Can smart medical sensors be used effectively to determine MEWS remotely for patients discharged from A\&E, hospital wards and ambulant care? \end{enumerate} \newpage \section{Tasks} The following milestones are defined for the research project: \begin{enumerate} \item Application design \begin{itemize} \item Detailed software architecture design, data model design \end{itemize} \item Application development and unit testing \begin{itemize} \item Database, API, authentication \item MEWS algorithm, alerts \item User interface \end{itemize} \item Application integration and deployment \begin{itemize} \item SSL certificate installation, deployment to public webserver \end{itemize} \item Case study data collection \item Case study data analysis and interpretation \item Written compilation of findings \item Reviews and adjustments \end{enumerate} The total available time for the project is 12 weeks. A timeline for each defined milestone is displayed in Figure \ref{gantt}. \begin{center} \begin{figure}[h] \includegraphics[width=\textwidth]{../figures/gantt.png} \caption{\label{gantt}Project Timeline} \end{figure} \end{center} \newpage \printbibliography \end{document}